Method of producing 7-amino-3-((/z/)-1-propenyl)-3-cephem-4-carboxylic acid or its benzohydryl ester

专利摘要:
This invention provides novel cephalosporin intermediates, 7 beta -amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and esters thereof having the general formula <IMAGE> wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protecting group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins. <IMAGE>
公开号:SU1435155A3
申请号:SU864027263
申请日:1986-04-16
公开日:1988-10-30
发明作者:Хоси Хидеаки；Окумура Юн；Абе Есио；Наито Такаюки；Абураки Симпеи
申请人:Бристоль-Мейерз Компани (Фирма)；
IPC主号:

专利说明:

where R is indicated, and acetaldehyde in the presence of lithium bromide in dichloromethane or. dimethylformamide at 0–20 ° C. In the resulting compound, the benzylidene group is removed (by treating with Gerard's reagent), or odCCH P (CbH5) from
COOR
modern benzylidene and benzhydryl group (by treatment with formic and hydrochloric acids) with the end product of the target product in free form or as an additive salt with hydrohalic acid.
i4 00
ate
C71 SL1

s
I The invention relates to a method for producing new organic compounds - 7-amino-3- (Z) -1-nponeHH. 3-cephem-4-carboxylic acid or its benzhydryl ester or its addition salts with hydrohalic acids, which are the first intermediates in the synthesis of cephalosporin antibiotics.
The aim of the invention is the creation of new intermediates, which make it possible to increase the selectivity of obtaining on their basis cephalosporin antibiotics with increased activity against gram-negative microorganisms.
Example 1. Preparation of diphenyl methyl (benzhydryl) 7-benzShideneamino-3-triphenylphosphonio methyl 3-cephem-4-carboxylic acid chloride ester.
To a suspension of 7-amino-3-chloromethyl-3-cephem-4 carboxylic acid hydrochloride diphenylmethyl ester (200 g, 0.44 mol) in (940 ml) was added 1N, NaOH solution (440 ml) at room temperature. The mixture was shaken for 10 minutes and the organic layer was separated. MgSO (75 g) and benzaldehyde (51 g, 0.48 mol) are added to this layer and the mixture is left to stand for 3 hours at room temperature. The reaction mixture is filtered and the insoluble materials are washed (200 ml). Triphenylphosphine (126 g, 0.48 mol) is added to the mixed filtrate and washes. The mixture is concentrated to about 400 ml under reduced pressure and left to stand for 4 days. The resulting viscous oil was diluted with ethyl acetate (1 L) and triturated to separate the indicated compound as a pale yellow crystalline powder, which was collected by filtration and dried under vacuum. Yield 322 g (96%).
185-190 ° C (decomp.). ;) Kvg,.
sy: 1780.1720
CHjCCz
 MS.KS and)
260
T, pieces
IR spectrum 1630,
UV spectrum (24100)
EXAMPLE 2. Preparation of 7-benzylidene-amino-3- (triphenylphosphoranylnden) -methyl-3-cephem-4-carboxylic acid (III) diphenylmethyl ester.
A mixture of 7-benzylideneamino-3-triphenylphosphonio-methyl-3-Cephem-4-carboxylic acid Diphenylmethyl ester
0
five
cm: 1770
0
five
0
five
0
five
0
five
h.porida (322 g, 0.42 mol) and 5 n. solution (252 ml) in (1.6 l) vigorously stirred for 15 min at room temperature. The organic layer is separated, dried over MgSO4 and concentrated to a volume of about 500 ml. The concentrate was diluted with acetone (1 L) with stirring to give a light yellow crystalline powder, which was collected by filtration, and 237 g (78%) of the desired substance melted at 195-198 ° C (decomp.).
IR: 1620.
UV spectrum: And 254- (23,000), 389 (22,000).
5ShR spectrum: J, CDCl, ppm: 2.56 and 3.16 (2H, ABq), 5.00 (1H, d, Hz), 5.23. (1H, d, Hz), 5 , 47 (1H, d, Hz), 6.95 (1H, s) i 7.2 7.8 (ZON, m) 8.55 (lH, s).
Example 3 Preparation of 7-amino-3- (2;) -1-propen-1-3-cephem-4-carboxylic acid hydrochloride diphenylmethyl ester (hydrochloride 1a).
To a cold solution of LiBr (19 g, 216 mmol) in a mixture of anhydrous dimethylforleamide (100 ml) and (300 ml) were added acetaldehyde (20 ml, 360 mmol) and 7-benzylideneamino-3- (triphensh1-phosphoranylidene) diphenylmethyl ether -methylZ-3-cephem-4-carboxylic acid (III) (15 g, 20 mmol) at -5 ° C. The mixture is left for 20 hours at a temperature of from -5 to -10 ° C, and then for 5 hours at room temperature. The resulting light brown solution was concentrated to a volume of about 100 ml under vacuum and added to two layers of solvent: ethyl acetate (400 ml) and water (400 ml). The upper layer was separated and diluted with isopropyl ether (400 ml). Silica gel (Wako gel C-100, 40 g) is added to the mixture. The mixture was shaken for 5 minutes and filtered through a diatom filter pad. The insoluble substances were washed with a mixed solvent of ethyl acetate ohm-isopropyl ether (1/1, 200 ml). The mixed filtrates and washes are concentrated to approximately 400 ml. A solution of Girard reagent at a concentration of 0.5 mol / L and methanol (60 ml) and acetic acid (6 ml) are added to the indicated concentrate and the mixture is stirred for
15 min at room temperature. The mixture is evaporated to a volume of approximately 200 ml and washed successively (200 ml), saturated aqueous NaHCO (3-20 ml) and brine (20 ml), dried over VMgSO, treated with charcoal and concentrated to a volume of about 50 ml. To the concentrate is added 1N. a solution of HCl in methanol (40 ml) at room temperature and left for 15 minutes. The mixture is evaporated to a volume of about 30 ml and diluted with ether (300 ml). The precipitate is collected by filtration and dried over P. to give 7.9 g of light yellow powder. A solution of the powder (7.3 g) in a mixed solution of oriental-methanol (80 ml) and ethyl acetate
Tata (40 ml) is added with NaHCOj until the pH of the mixture is 8. The nous layer is washed with saturated aqueous NaCl (5 ml), dried over MgS and concentrated to a volume of about 20 ml. The resulting solution was diluted with isopropyl ether (10 ml) and seeded with a crystal.
10 кого of substance 1a. An additional amount of isopropyl ether (30 ml) is slowly added to the mixture while stirring. After 15 minutes, colorless crystals are collected.
15, washed with isopropyl ether (10 ml) and dried over vacuum, yielding 4.3 g (94%) of the title compound (Z / E 9/1, according to highly sensitive liquid
(80 ml) is treated with charcoal, JQ chromatography) (Lichrosorb RP-18,
the mixture is concentrated to approximately 100 ml, the seed of the crystalline hydrochloride of the compound indicated is placed in it, diluted slowly with ether (80 ml) and stirred for 1 hour. The isolated colorless crystals were collected by filtration and dried over 5 under a vacuum, yielding 6.3 g (71%) of the compound. This product is a mixture of isomers Z and E with respect to the propenyl part in the 3-position (Z / E-9/1, according to the data of highly sensitive liquid chromatography) (Lichrosorb RP-18, 80% methanol - pH 7 , 2 phosphate buffer,
254 nm, 1 ml / min). CVG
80% methanol (pH 7.2 phosphate buffer 254 nm, 1 ml / min).
IR spectrum: 1765, 1730.

25
UV spectrum: 289 (185).
NMR spectrum;
KVG Alax 1
EtOH
MOIKC 1
S. CDCl
CM
them
3450
/with . IticMj30
35
 L
Max
FTOH max 1
CM
2850,
/ s-% V.
"CE smU40
45
IR spectrum 1785, 1725.
UV spectrum 287 (1/3).
Nuclear Magnetic Resonance Spectrum (DMSO-s), ppm: 1.47 / 27/1011, dd, J 7.2 Hz, CRCH, cis), 1.74 (3 / 10H, d, J 7 Hz , -CECH, trans), 3.47 and 3.8 (each 1H, d, J 16 Hz); . 5.13 UH d, J 4.5 Hz, nN); 5.23 (1H, d, J 4.5 Hz, 7-H), 5.62 (1H, d-q, J 10 and 7 Hz,); 6.24 (1H, dd, J 10 and 2 Hz, 3-CIS, 6.61 (1H, s, CHPHj)} 7.35 / YUN, m, Pn-N).
Example 4. Preparation of diphenyl- 50 methyl 4-ether 7-aMHHo-3- (Z) -1-propen-1-yl} -3-cephem-4-carboxylic acid (1 a).
To a stirred suspension of diphenylmethyl ester hydrochloride 55 of 7-amino-3- (iC) -1-propen-1-yl-3-cephem-4-carboxylic acid (5 g, 11.3 mmol) in (20 ml) and ethylace-
, hours per ml 1.43 (ZN, dd; J 2 and 7 Hz, 1.66 C2H, broad s, disappears when D ,, NH,) {3.23 and 3.55 (each 1H, d, J 17 Hz, 2-H); 4.73 (1H, dd, J 4.5. Hz, 6-H); 4.96 (1H, d, J 4.5 Hz, 7-H); 5.46 (1H, d - KV J 10 and 7 Hz,).
Example 4. 7-AMHHo-3-f (Z) propen-1-yl cef-3-em-4-carboxylic acid, 1c.
To a stirred solution of 260 anisole and 1.38 l of trifluoroacetic acid, cooled to 0 ° C, 149.7 g (0.338 mol) of 7-amino-3- (E) -1-propen-1-yl diphenylmithyl ester are added. -Z-cephem-4-carboxylic. hydrochloride acid (0.338 mol). The resulting suspension is then stirred at room temperature for 1 hour; Most of the excess trifluoroacetic acid is removed under vacuum on a rotary evaporator. The clear surface solution is drained and the resulting suspension is triturated with 1.5 liters of anhydrous ether for 1 hour. The crystalline product is filtered and dried to obtain 87.24 g of 1B trifluoroacetate. This 87.24 g of trifluoroacetate is suspended and stirred in 900 ml of water (pH about 2.5). The mixture is cooled to 5 ° C and then NaHCOj is added to adjust the pH to 0.6 with potate (40 ml) until the pH of the mixture becomes 8. The organic layer is washed with saturated aqueous NaCl (5 ml), dried over MgSO4. and concentrate to a volume of about 20 ml. The resulting solution was diluted with isopropyl ether (10 ml) and seeded with crystalline material 1a. An additional amount of isopropyl ether (30 ml) is slowly added to the mixture while stirring. After 15 minutes, the colorless precipitated crystals were collected by filtration, washed with isopropyl ether (10 ml) and dried over vacuum to give 4.3 g (94%) of the title compound (Z / E 9/1, according to a highly sensitive liquid
Q chromatography) (Lichrosorb RP-18,
80% methanol - pH 7.2 phosphate buffer, 254 nm, 1 ml / min).
IR spectrum: 1765, 1730.

five
UV spectrum: 289 (185).
NMR spectrum;
KVG Alax 1
EtOH
MOIKC 1
S. CDCl
CM
them
3450,
/with . IticMj0
five
0
five
0
five
, ppm: 1.43 (ZN, dd; J 2 and 7 Hz,) -, 1.66 C2H, broad s, disappears when D ,, NH,) {3.23 and 3.55 ( each 1H, d, J 17 Hz, 2-H); 4.73 (1H, dd, J 4.5. Hz, 6-H); 4.96 (1H, d, J 4.5 Hz, 7-H); 5.46 (1H, d - KBr J 10 and 7 Hz,).
Example 4. 7-AMHHo-3-f (Z) 1-propen-1-yl cef-3-em-4-carboxylic acid, 1c.
To a stirred solution of 260 ml of anisole and 1.38 l of trifluoroacetic acid, cooled to 0 ° C, was added 149.7 g (0.338 mol) of 7-amino-3- (E) -1-propen-1-yl diphenylmethyl ester | -Z-cephem-4-carboxylic. hydrochloride acid (0.338 mol). . The suspension obtained is then stirred at room temperature for 1 hour; Most of the excess trifluoroacetic acid is removed under vacuum on a rotary evaporator. The residual surface solution is drained and the resulting suspension is triturated with 1.5 liters of anhydrous ether for 1 hour. The crystalline product is filtered and dried over to obtain 87.24 g of 1B trifluoroacetate. These 87.24 g of trifluoroacetate are suspended and stirred in 900 ml of water (pH about 2.5). The mixture is cooled to 5 ° C and then pH is adjusted to 0.6 with 12 n. HCi solution. The yellow solution is treated with charcoal and the suspension is filtered on a diatom filter pad. The resulting solution is cooled to and the pH is adjusted to 2.0 with 20% NaOH. The suspension is kept for 1 hour in the refrigerator to aid crystallization. The crystals are collected, washed with 800 ml of water, 800 ml of acetone and dried under vacuum at room temperature.
Yield 69.4 g (.85.5%). Contains 9.7% trans-isomer Soyredeno using high-sensitivity liquid chromatography on a RP-18 MERCK column; H (NH4) P04 0.1 mol 95 ml + + CHjCN 3 ml, detected at 290 nm).
Example 5. Preparation of 7-amino 3-L (Z) -1-propen-1 -yl-3-cephem-4-carboxylic acid, 1c.
A solution of the phosphoranyl compound III obtained in Example 2 (50.0 g, 68.7 mmol) in CHCl (500 ml) is mixed with a solution of lithium bromide (29.8 g, 343 mmol) in anhydrous dimethylformamide (170 ml) containing a small amount of CH, Cl; j (10 ml), and then with an aqueous addetaldehyde (39 ml, 687 mmol) obtained from paraldehyde and toluene sulfonic acid by distillation. The mixture is placed in a closed vessel and maintained for 2 days. The reaction mixture was evaporated, the residual liquid was diluted with EtOAc (800 ml), washed with water (ml) and saturated NaCl solution (300 ml) and evaporated to give a protected 3-propellane derivative in the form of a foamy solid (34 g), which used for subsequent reaction without further purification.
The resulting crude material is treated with 98% formic acid (35 ml) and concentrated HC1 (17 ml, 206 mmol) at room temperature for 1 hour. Water (350 ml) is added to the reaction mixture to separate an oily layer, which
where V. has the indicated meanings, is subjected to interaction with acetal 1556
washed with ethyl acetate (3.10 ml). The pH of the aqueous layer is adjusted to about 3 with 4 n. NaOH solution (about 65 ml) with stirring to obtain a crystalline solid, which is collected by filtration and washed with water (50 ml), provided the desired compound (1B,
 : 3420,
8.7 g, 59%). High performance liquid chromatography (Lichrosorb RP-18, 4-300 ml, MeOH; phosphate buffer (pH 7) 15:85) showed that this product was a mixture of 83: 17 Z and E isomers with respect to double-z 3-propenyl groups. M.p. 20o s (dec).
IR spectrum:. 1805, 1620.
UV spectrum: A max (pH 7 phosphate buffer), nm (6 V 283 (8900).
5WD spectrum: (D O + NaHCOj), h. By 1.69 and 1.88 (GN, each d, J 6.0 Hz, Z and E-CH CH-jj); 3.38 and 3.72 (2H, Abq, J 17 Hz, H-2), 5-18 (1H, d, J., 5.0 Hz, H-6), 5.51 (W, d, H-7); approximately 5.8 C1H, M, -CH CH-CHj) and 6.06 (1H, d, J 11 Hz, -CH CH-CH3). .
Found,%: C 50.20} H, 4.94, N, 10.93; S 12.82,
C, o &, ,,,
Calculated,%: C 49.99 {H 5.03; N 11.66; s 13,34.v

权利要求:
Claims (1)
[1]
Invention Formula
Method for preparing 7-amino-3- (Z) -1-propenyl-3-cephem-4-carboxylic acid or its benzhydryl ester of the formula 1
NgK s
ABOUT
{
Bssn
sns
COOR
where R is a hydrogen atom or a benzhydryl, or a yus of additive salts with halohydrogen acids, characterized by mules II
so that the connection is forced
COOR
 Р1СбН5
in the presence of lithium bromide in dichloromethane or dimethylformamide with, in the resulting compound of formula III
-N.
s
COOR
eight
Nz
ten
where K has the indicated values, the benzylidene group is removed by treatment with Gerard's reagent, or the benylylidene and benzhydryl group is simultaneously treated with formic and hydrochloric acid and the desired product is precipitated in free form or as an additive salt with a hydrohalic acid.

类似技术:

---

公开号 | 公开日 | 专利标题

---

SU1435155A3|1988-10-30|Method of producing 7-amino-3-|-1-propenyl)-3-cephem-4-carboxylic acid or its benzohydryl ester or additive salts thereof with hydrogen halide acids

---

SU1436882A3|1988-11-07|Method of producing diphenylmethyl ether of 7-benzylidene-amino-3-| - cephem-4-carboxylic acid

---

SU676166A3|1979-07-25|Method of obtaining cephalosporins or salts thereof

---

JP2825655B2|1998-11-18|Purification method of 3-cephem-4-carboxylic acid derivative

---

DK147513B|1984-09-10|ANALOGY PROCEDURE FOR THE MANUFACTURE OF CEFUROXIMESTERS

---

US4147863A|1979-04-03|7-D-|-mandelamido-3-|vinyl-3-cephem-4-carboxylic acid

---

US4699979A|1987-10-13|7-amino-3-propenylcephalosporanic acid and esters thereof

---

JPH0748383A|1995-02-21|Bicyclic beta-lactam/paravenn complex

---

US4902793A|1990-02-20|Process for preparing 3-alkoxymethylcephalosporins

---

SU546282A3|1977-02-05|The method of obtaining 7-α-amino-7 methoxy-cephalosporin esters

---

US4139618A|1979-02-13|Cephalosporin type antibacterials

---

US4094978A|1978-06-13|3-propenyl derivatives of cephalosporin, compositions and their use

---

US4237279A|1980-12-02|Crystalline 3-hydroxycephalosporin solvates

---

EP0084611A1|1983-08-03|Crystalline, solvate-free D-|-4-hydroxy-phenylglycyl-chloride hydrochloride

---

US4281117A|1981-07-28|Process for 3-chloro cephalosporin nucleus

---

US4304717A|1981-12-08|Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives

---

US4171303A|1979-10-16|Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives

---

US4139702A|1979-02-13|Process for preparing cephalosporines

---

HU200184B|1990-04-28|Process for producing 3-|-3-cefem-4-carboxilic acid derivatie

---

US4304909A|1981-12-08|Process for producing 7-|-α-|-α-|acetamido)-3-|thiomethyl)-.DELTA.3 -cephem-4-carboxylic acid and a pharmaceutically acceptable salt thereof

---

EP0014565B1|1983-02-23|3-hydroxycephalosporin solvates and process for their production

---

US4334065A|1982-06-08|Cephalosporin intermediates

---

US4115646A|1978-09-19|Process for preparing 7-aminocephalosporanic acid derivatives

---

KR790001503B1|1979-10-24|Process for preparing 3-cephalosporing esters

---

SU457224A3|1975-01-15|The method of obtaining -substituted carbamoyloxymethyl cephalus

同族专利:

---

公开号 | 公开日

---

FI861634A|1986-10-23|

---

DK182486D0|1986-04-21|

---

EG18001A|1991-11-30|

---

CY1571A|1991-12-20|

---

OA08245A|1987-10-30|

---

ES8800236A1|1987-10-16|

---

HUT41033A|1987-03-30|

---

FR2580652A1|1986-10-24|

---

ZW9086A1|1986-12-03|

---

CS270435B2|1990-06-13|

---

PT82436A|1986-05-01|

---

DE3613365C2|1989-06-15|

---

ATA106786A|1990-07-15|

---

AU5616886A|1986-11-06|

---

IE59014B1|1993-12-15|

---

SE8601825D0|1986-04-21|

---

NO164659C|1990-10-31|

---

JPH0327554B2|1991-04-16|

---

CN86102630A|1987-02-04|

---

ZM4286A1|1989-03-27|

---

BE904646A|1986-10-21|

---

AT392072B|1991-01-25|

---

GR861065B|1986-09-01|

---

FI84268C|1991-11-11|

---

HK106290A|1990-12-28|

---

FI84268B|1991-07-31|

---

CN1015714B|1992-03-04|

---

NL192205B|1996-11-01|

---

GB2173798B|1988-11-30|

---

AU589170B2|1989-10-05|

---

PT82436B|1988-11-30|

---

NO164659B|1990-07-23|

---

DK163584B|1992-03-16|

---

MY100694A|1991-01-17|

---

DE3613365A1|1987-01-02|

---

IE861048L|1986-10-22|

---

ES554215A0|1987-10-16|

---

DD244557A5|1987-04-08|

---

NL192205C|1997-03-04|

---

JPS61249989A|1986-11-07|

---

DK163584C|1992-08-10|

---

GB8609661D0|1986-05-29|

---

GB2173798A|1986-10-22|

---

CH671399A5|1989-08-31|

---

FI861634A0|1986-04-17|

---

NZ215717A|1989-06-28|

---

SG90890G|1991-01-18|

---

NL8601011A|1986-11-17|

---

YU43697B|1989-10-31|

---

IT1228241B|1991-06-05|

---

YU65986A|1987-12-31|

---

LU86402A1|1986-11-05|

---

FR2580652B1|1989-01-06|

---

SE500217C2|1994-05-09|

---

CA1273629A|1990-09-04|

---

ZA862985B|1986-12-30|

---

SE8601825L|1986-10-23|

---

HU195223B|1988-04-28|

---

IT8620162D0|1986-04-21|

---

NO861430L|1986-10-23|

---

AR242581A1|1993-04-30|

---

KR860008189A|1986-11-12|

---

CS287286A2|1989-11-14|

---

DK182486A|1986-10-23|

引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

GB1342241A|1970-01-23|1974-01-03|Glaxo Lab Ltd|Cephalosporin compounds|

---

US4110534A|1970-01-23|1978-08-29|Glaxo Laboratories Limited|Process for the preparation of 3-vinyl and substituted vinyl cephalosporins|

---

US3769277A|1970-01-23|1973-10-30|Glaxo Lab Ltd|Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group|

---

US4065620A|1971-06-14|1977-12-27|Eli Lilly And Company|3- vinyl cephalosporins|

---

US4409214A|1979-11-19|1983-10-11|Fujisawa Pharmaceutical, Co., Ltd.|7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof|

---

US4520022A|1983-01-28|1985-05-28|Bristol-Myers Company|Substituted vinyl cephalosporins|

---

AU566944B2|1983-10-07|1987-11-05|Gist-Brocades N.V.|Preparation of 3-cephem derivatives|US4708955A|1985-06-24|1987-11-24|Bristol-Myers Company|3-propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof|

---

US4847373A|1987-02-26|1989-07-11|Bristol-Myers Company|Production of 3-allyl- and 3-butenyl-3-cephems|

---

DE3933934A1|1989-10-03|1991-04-11|Bayer Ag|METHOD FOR PRODUCING 7-AMINO-3 --1-PROPEN-1-YL) -3-CEPHEM-4-CARBONIC ACID|

---

EP0503453B1|1991-03-08|2001-05-09|Biochemie Gesellschaft M.B.H.|New process for the production of cephalosporines and novel intermediates in this process|

---

AT399876B|1992-02-05|1995-08-25|Biochemie Gmbh|Purificn. of 7-amino-3--1-propen-1-yl)-3 -cephem-4-carboxylic acid - useful in prodn. of broadband antibiotics|

---

AT205214T|1992-02-05|2001-09-15|Biochemie Gmbh|METHOD FOR PURIFYING A 3-CEPHEM-4-CARBOXYL ACID DERIVATE|

---

JPH07173168A|1993-07-14|1995-07-11|Sumitomo Chem Co Ltd|Cephem compound, its production and utilization of the compound for production of cephem antibiotic substance|

---

CN1711271A|2002-10-08|2005-12-21|兰贝克赛实验室有限公司|Process for the preparation of -isomer enriched 7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid|

---

EP1678186A4|2003-10-30|2007-04-25|Cj Corp|Processes for the preparation of cephem derivatives|

---

JP4046708B2|2004-06-04|2008-02-13|明治製菓株式会社|Method for producing 3-alkenylcephem compound|

---

WO2006048887A1|2004-11-01|2006-05-11|Hetero Drugs Limited|A novel process for preparation of cefprozil intermediate|

---

CN103183686B|2011-12-30|2016-06-29|浙江新和成股份有限公司|The preparation method of 7 beta-amino-7 α-methoxyl group-3-cephem compounds|

法律状态:

优先权:

---

申请号 | 申请日 | 专利标题

---

US72587185A| true| 1985-04-22|1985-04-22|

---